To confirm the role of SREBP-1c in ZFD-induced lipogenesis and steatosis, we treated ZFD-fed CONVR mice with Srebf1-specific antisense oligonucleotides (ASO) for three weeks, causing a reduction of hepatic Srebf1 expression by 70% (Supplementary Figure 3A). The gene discussed is SREBF1; the disease is steatosis.