Clinically evident chromium deficiency is extremely rare and has not been observed in healthy individuals on a typical diet.15 In humans, chromium plays a critical role in the metabolism of carbohydrates and fats, by enhancing the action of insulin, as first discovered in 1955 in a rat model of impaired glucose tolerance.16 This finding was confirmed in humans by different studies showing that chromium can reduce the risk of impaired glucose tolerance and improve glycemic control, especially in case of type 2 diabetes mellitus or glucose intolerance.17,18. Here, INS is linked to Impaired glucose tolerance.