GPHN and major depressive disorder: Improvements in inflammatory-oxidative parameters during selenium supplementation were examined in women with PCOS (polycystic ovary syndrome), alongside hormonal profiles and mental health.53 Co-administration of probiotics and selenium resulted in a significant improvement in depression-anxiety and stress scores compared to placebo, reduced CRP and malondialdehyde values, and increased GPH levels, in parallel to hormonal and metabolic improvements (eg, in dyslipidemia and insulin sensitivity).