CRTC3 and major depressive disorder: For chromium levels, only 1 suggestive association has been reported, with rs12915189 in the CRTC3 (CREB Regulated Transcription Coactivator 3) gene.99CRTC3 has a role in catecholamine signaling regulating glucose/fatty acid oxidation and energy balance,100 suggesting a potential link with atypical symptoms of depression involving appetite/eating behaviors.