Improvements in inflammatory-oxidative parameters during selenium supplementation were examined in women with PCOS (polycystic ovary syndrome), alongside hormonal profiles and mental health.53 Co-administration of probiotics and selenium resulted in a significant improvement in depression-anxiety and stress scores compared to placebo, reduced CRP and malondialdehyde values, and increased GPH levels, in parallel to hormonal and metabolic improvements (eg, in dyslipidemia and insulin sensitivity). This evidence concerns the gene GPHN and metabolic syndrome.