For acute myeloid leukemia (AML) cells expressing CD47 and TIM‐3 antigens, anti‐CD47 antibody (aCD47)‐functionalized protein nanogel particles (CR‐TNG) anchor to leukemia cells by binding CD47 and TIM‐3, blocking CD47‐SIRPα interactions to promote macrophage phagocytosis of AML cells. Here, CD47 is linked to leukemia.