CTSS and neoplasm: The tumor microenvironment exhibits abnormal expression of enzymes such as matrix metalloproteinases, cathepsins, phospholipases, and redox enzymes, and the development of enzyme‐responsive NPs for tumor microenvironment‐targeted therapy represents another effective strategy for intelligent NPs to deliver payloads to desired targets.[149] Previous researchers designed an oral NPs (βGlus‐ZnD) modified with βGlus that accumulates in tumor regions via macrophage homing effects.