Nanomaterials are widely used in tumor immunotherapy.[174] As we know, antigen presentation plays an important role in tumor treatment.[175, 176, 177] Therefore, previous studies have developed NPs to specifically modulate immune cells, thereby obtaining potent anti‐tumor activity.[178] Folate (FA) functionalization on liposome surfaces can attract natural IgM for non‐covalent binding. This evidence concerns the gene CD40LG and neoplasm.