ALB and neoplasm: assembled highly cytotoxic mertansine (DM1) and Evans blue (EB) into NPs (EB‐ss‐DM1), where EB covalently binds albumin for tumor delivery and DM1 release to suppress tumor growth.[52] However, challenges remain: 1) Albumin corona formation: Albumin can form a “protein corona” on NPs surfaces, altering delivery and targeting properties[2]; 2) Functional alterations of albumin: potential functional alterations of albumin by loaded NPs; 3) NPs release concerns: Failure to release drugs from albumin may induce toxicity.