,12 Several studies have established that inhibiting the phosphorylation-dependent activation of Stat3 can significantly ameliorate both the acute and chronic phases of renal injury.13, 14, 15 However, recent evidence indicates other post-translational modifications are also crucial for its transcriptional activity, and conflicting views exist on the role of Stat3 in AKI.16, 17, 18 This gap has sparked profound interest and highlighted the need for further research. This evidence concerns the gene STAT3 and acute kidney injury.