SUN1 and Hutchinson-Gilford progeria syndrome: Moreover, SUN1 silencing in HGPS fibroblasts rescues the deformed nuclear morphology,[28] whereas SUN2 depletion fails to restore progerin‐induced nuclear deformation.[4] These observations highlight the role of SUN1 upregulation in nuclear deformation as a molecular hallmark of the pathological signature of HGPS.