Building on previous reports that SUN1 and SUN2 are not functionally equivalent for nuclear connection to the actin cytoskeleton,[54] and that SUN1, but not SUN2, is upregulated in HGPS cells,[28] we investigated whether doxycycline‐activated progerin expression could remodel the molecular connectivity of LINC‐associated proteins to the nucleus via upregulation of SUN1. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.