To test this hypothesis, we first examined whether progerin expression alters internuclear chromatin dynamics by comparing telomere motion in dermal fibroblasts derived from a 3‐year‐old healthy individual and a same‐aged patient with HGPS, denoted as 3YR (control) and 3YR (HGPS), respectively (Figure6A–C). Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.