Emerging evidence has shown that Fn14 contributes to regulating wound repair, inflammation, angiogenesis, migration, and invasion.[11] Further, Fn14 exerts tumor suppressive activity by promoting apoptosis in endometrial cancer, colon carcinoma, and hepatocellular carcinoma.[26, 27, 28] In addition, our previous study also revealed that Fn14 reverses chemoresistance by promoting the degradation of TP53‐R248Q in ovarian cancer. Here, TNFRSF12A is linked to colon carcinoma.