Fn14 has been implicated that modulating invasion and migration of cancer cells mainly rely on activation of downstream signal transduction through TNF receptor–associated factor 2, Rho guanosine triphosphatase, and guanine nucleotide exchange factor.[29] Interestingly, our results revealed that Fn14 regulates migration and invasion in the EOC cells by inhibition of EMT. This evidence concerns the gene TNFRSF12A and cancer.