Recent research revealed that exosome derived from human umbilical cord mesenchymal stem cells (hucMSC-Ex) attenuate inflammatory bowel disease (IBD) by miR-129-5p targeting of ACSL4, which inhibits lipid peroxidation (LPO) and ferroptosis, thereby reducing intestinal inflammation and repairing damage [57]. This evidence concerns the gene ACSL4 and inflammatory bowel disease.