PRMT5 and colorectal carcinoma: CPT‐11 exerts cytotoxic effects by inducing DSBs that lead to extensive DNA damage and trigger the release of double‐stranded DNA (dsDNA) from drug‐sensitive CRC cells,[26] prompting further investigation into the effects of PRMT5 on CPT‐11 induced DNA damage and dsDNA leakage in CRC cells.