Activation of the cGAS‐STING axis induces the expression of innate immune genes, including Interferon beta (IFNβ), interferon‐stimulated genes (ISGs), C–C motif chemokine ligand 5 (CCL5), and the C–X–C motif chemokine ligand 10 (CXCL10).[16, 38] Significantly higher levels of IFNβ, ISG15, CCL5, and CXCL10 were observed in PMS2KO cells compared to PMS2WT cells in both SW480 and CT26 cell lines, suggesting that PMS2 deficiency positively regulates the activation of the cGAS‐STING signaling pathway in MSS CRC (Figure 5E–H; Figure S6C–F, Supporting Information). This evidence concerns the gene CXCL10 and Marinesco-Sjogren syndrome.