In order to analyze the immune activation profile, PMS2 wild‐type (PMS2WT), PMS2 knockout (PMS2KO), and PMS2 overexpression in PMS2KO cells (PMS2Rescd) were generated in both human SW480 and mouse CT26 tumor cells, both of which are considered as MSS CRC cell lines. This evidence concerns the gene PMS2 and colorectal carcinoma.