From a neuropathologic standpoint, AD is defined by the simultaneous presence of Aβ plaques and tau aggregates, satisfying the criteria for Alzheimer's disease neuropathologic change (ADNC).[6] However, this dual pathology hinders the investigation of tau hyperphosphorylation as an independent process, thereby limiting the identification of common mechanisms across different tauopathies. This evidence concerns the gene MAPT and Alzheimer disease.