Specifically, the presence of the PIK3CAH1047R mutation in MT‐cell‐derived exosomes activated the transformation of fibroblasts into CAFs through PI3K/NF‐κB, and the CAFs released a large amount of IL6, which promoted EMT by activating the STAT3 signaling pathway at the primary tumor site, and activation of macrophages in the distal organs, which led to the formation of a PMN leads to directional metastasis of tumor cells at the primary site. Here, PIK3CA is linked to neoplasm.