PIK3CA and colorectal carcinoma: Class IA phosphatidylinositol 3‐kinase (PI3K) are heterodimeric lipid kinases comprising a p110 catalytic subunit and a p85 regulatory subunit.[22] The PIK3CA, responsible for encoding the p110α catalytic subunit of PI3K, exhibits a mutation frequency of over 25% in patients with CRC, and the majority of PIK3CA mutations are concentrated at three specific sites: E542K and E545K in the helix domain, and H1047R in the kinase domain.[23] The PIK3CAH1047R mutation is also associated with CRC metastasis.[24, 25] However, the role of PIK3CAH1047R mutation in CRC metastasis remains unclear.