CD8+ T cells activated by immunotherapy can trigger ferroptosis in tumor cells through IFN‐γ secretion, enhancing the cytotoxic effect on cancer cells.[31] A comprehensive understanding of the mechanisms that regulate PD‐L1 expression and T lymphocyte infiltration may help develop novel therapeutic strategies to improve the efficacy of PD‐1/PD‐L1 blockade. The gene discussed is CD8A; the disease is neoplasm.