Pathologically elevated Piezo1 in infarct zone could lead to the activation of calcium influx, ROS production, inflammatory response, and collagen fibril organization, which eventually develops into heart failure.[4, 5, 13, 17] We used virus to knockdown the elevated Piezo1 caused by MI could improve cardiac function via recovering the calcium influx, myocardial fibrosis, and inflammatory response. The gene discussed is PIEZO1; the disease is heart failure.