Masson's trichrome staining revealed similar results (Figure 1k,l), that the reversal of Piezo1 expression reduced the infarction size to 18.9% and increased the LV wall thickness to 1.47 mm 4 weeks post‐MI, compared to 24.4% and 1.0 mm in the MI+shCtrl group. This evidence concerns the gene PIEZO1 and myocardial infarction.