Pathologically elevated Piezo1 in infarct zone could lead to the activation of calcium influx, ROS production, inflammatory response, and collagen fibril organization, which eventually develops into heart failure.[4, 5, 13, 17] We used virus to knockdown the elevated Piezo1 caused by MI could improve cardiac function via recovering the calcium influx, myocardial fibrosis, and inflammatory response. Here, PIEZO1 is linked to myocardial infarction.