Although the elevated Piezo1 level did not significantly upregulate Col1a1, histological evaluations showed overexpression of PIEZO1 resulted in a larger infarction size (19.6%) and smaller LV wall thickness (1.7 mm) compared to MI+P (17.4%, 2.0 mm) and MI+P+oeCtrl (17.3%, 2.0 mm) (Figure 5f,g). The gene discussed is COL1A1; the disease is infarction.