Some of these proteins, including those belonging to the Complement factors (specifically Complement factor I, B, D and H), Sex Hormone Binding Protein (SHBP), Galectin‐3 binding protein (Gal‐3BP), Afamin and Antithrombin III, have been documented in intervention studies focusing on proteome changes after weight loss in individuals with overweight or obesity as a starting point.13, 14, 15, 16. This evidence concerns the gene CFI and Obesity.