TGR5 is encoded by the Gpbar1 gene and functions as a receptor for bile acids, especially GI metabolites SBAs.[14] Consequently, the serum bile acids profiles, specifically LCA and its derivatives in various stages of liver fibrosis (F0–F4) in MASLD patients (n = 550) were investigated. This evidence concerns the gene GPBAR1 and metabolic dysfunction-associated steatotic liver disease.