Therefore, OA-induced lowering of EIF2AK1 is PINK1 independent, and, recently, it was reported that silencing factor of the ISR (SIFI), an E3 ligase complex, mutated in early onset ataxia and dementia can regulate the degradation of EIF2AK1 to promote survival of cells undergoing mitochondrial import stress (30). This evidence concerns the gene EIF2AK1 and dementia.