Given this, we propose that SARM1’s role should also be investigated in other types of mitochondrial neurodegenerative disorders, such as Leber hereditary optic neuropathy (LHON), which is caused by mitochondrial DNA mutations and leads to RGC degeneration similar to that seen in ADOA (61, 100, 101). Here, SARM1 is linked to Leber hereditary optic neuropathy.