SARM1 and Charcot-Marie-Tooth disease type 2A1: SARM1 can be activated downstream of mitochondrial dysfunctions (42, 43), and a recent study showed that SARM1 activation further exacerbates certain mitochondrial phenotypes in distal parts of neurons in a rat model of CMT2A, implying the existence of a SARM1-mitochondrial feedback loop (41).