The absence of TBX binding consensus appearing in this analysis, in conjunction with the enrichment of the TCF/LEF signature, suggested that also in CRC cells, as previously found in developing mouse forelimbs (29), the association of TBX3 to these loci depends on the physical interaction of TBX3 with components of the Wnt/β-catenin transcriptional complex. This evidence concerns the gene TBX3 and colorectal carcinoma.