When C&R-LoV-U against TBX3 was performed in other human CRC cells, such as DLD1 and SW620, that instead of activating mutations in CTNNB1 carry loss of function alleles of APC (44), comparable enrichment for TBX3 signal was observed (Fig. 2 E and F). The gene discussed is APC; the disease is colorectal carcinoma.