Of note, overlapping genomic occupancy between TBX3 and β-catenin at relevant cancer-inducing genes, such as MYC, RAS, and STAT1 is also found in hepatocellular carcinoma (HCC) cells, both in cell lines (HepG2 from ENCODE; see Methods) and in two independent patient-derived HCC biopsies (our data) (Fig. 3E). The gene discussed is MYC; the disease is cancer.