The same authors, in a previous prominent article, had identified an interplay between β-catenin and another member of the TBX family of transcription factors, TBX5, which together with YAP1 and β-catenin was essential to mediate survival and tumorigenesis of several β-catenin-driven cancers, including CRC (80). The gene discussed is TBX5; the disease is colorectal carcinoma.