Next, we scanned >15 CCF1 crosses using each of the other 3 murine cancer models (Figures 1C-1E) and found significant heritability for each (Figure 1F): 0.33 for EMT6 (p < 1 × 10−4), 0.19 for CT26 (p = 2 × 10−4), and 0.18 for AT3 (p = 0.017). This evidence concerns the gene DDX53 and cancer.