Moreover, it has been reported that AD and CAA often coexist in patients with a rapidly progressive form of AD.3 A previous study by our group showed that these CAA imaging markers had distinctive associations with cortical atrophy and cognitive functions in relation to Aβ uptake on positron emission tomography (PET).4 However, the association between CAA imaging markers and downstream AD processes, including tau hyperphosphorylation, neuroinflammation, and neurodegeneration other than Aβ burdens, has not been extensively studied. Here, MAPT is linked to Alzheimer disease.