Indeed, previous studies have shown that lobar CMBs are associated with tau pathology independent of amyloid pathology.49 The presence of CAA has also been associated with regional production of paired helical filament tau.50 Future research that explores the effect of CAA on these downstream AD plasma biomarkers independently of Aβ may provide insight into the mechanisms by which CAA-like ARIA-hemorrhage contributes to the prognosis of patients receiving amyloid-targeted therapy. The gene discussed is MAPT; the disease is Alzheimer disease.