At the transcriptomic level, we identified that in addition to genes already described in aging phenotypes in EM T cells such as PDCD1, GZMH and CXCR3, new genes (NUAK1, LINC02384, CCL2, UCP2, SLC40 A1, SOCS2, PTGDS, NRGN, TNFRSF4, PTGER2, IER5, and HIST1H1E) that could help us to predict the phenotype of the MSS patient. The gene discussed is TNFRSF4; the disease is Marinesco-Sjogren syndrome.