Another striking example of the therapeutic application of ferritin nanoparticles is the work of Dong et al. (2022), which demonstrates the modification of ferritin nanocarriers with CendR peptides to overcome the limited permeability of ferritin in tumor tissues.177 By attaching tumor-penetrating peptides such as D(RGERPPR) to the outer surface of ferritin nanocages, Dong et al. achieved dual-targeting capabilities, enhancing both the uptake and cytotoxicity of paclitaxel-loaded ferritin nanoparticles in cancer cells expressing TfR1 and NRP-1 receptors. This evidence concerns the gene TFRC and cancer.