A similar inflammatory involvement is observed in Alzheimer’s disease (AD), where several critical transcription factors, including Repressor Element 1-Silencing Transcription/Neuron-Restrictive Silencer Factor (REST/NRSF), Signal Transducer and Activator of Transcription 3 (STAT3), and Nuclear Factor Erythroid 2-Related Factor 2 (NRF2), are central to the disease’s pathophysiology. The gene discussed is REST; the disease is Alzheimer disease.