MAPT and neurodegenerative disease: The 5XFAD/Rubicon KO mouse model used herein recapitulates multiple facets of human neurodegenerative diseases including robust Aβ deposition, tau phosphorylation, neuronal loss, reactive microgliosis, neuroinflammation including NLRP3 activation and IL-1β production, cumulatively leading to memory and learning impairment14,26,35.