The 5XFAD/Rubicon KO mouse model recapitulates multiple markers of human neurodegenerative disease and specifically AD pathology, including robust Aβ deposition, select tau pathology, region specific neurodegeneration, memory and cognitive impairment, and reactive microgliosis, neuroinflammation, and IL-1β architecture that mimics human disease29–33. Here, MAPT is linked to Alzheimer disease.