VEGFA and cancer: Additionally, it significantly reduced the levels of key proteins in cancer progression, including those involved in cell proliferation (cyclin D1), metastasis, cyclooxygenase-2 (COX-2), angiogenesis, vascular endothelial growth factor (VEGF), and resistance to apoptosis, such as Bcl-2, Bcl-xL, IAP-1, IAP-2 and survivin [42].