A scenario that impressively illustrates involvement of both iDAMPs and cDAMPs in activation of DCs refers to research on ICD in tumor immunology: cDAMPs like HMGB1, HSPs, eATP, and CALR, as well as iDAMPs such as IFN-I are essential DAMPs required to activate DCs to initiate effective antitumor immune responses (275–277). This evidence concerns the gene HMGB1 and neoplasm.