PKD2 and dementia: It was apparent that while most TRP genes were not altered by dementia, few (most significantly PKD2) were consistently down-regulated in all studied cell subpopulations of dementia brains, a handful was upregulated there (TRPV1, in both glutamatergic and GABAergic neurons, but not in non-neuronal cells), all the while some were altered in cell type-specific patterns (e.g., TRPM8 downregulated in dementia glutamatergic neurons while upregulated in GABAergic ones) (Figure 4A; Supplementary Figure S8A).