The developmental regulation of TRP channel expression TRPV2, TRPM2, and TRPV3, or TRPC3-specific expression in the cerebellar cortex, and their modulation in aging and dementia, underscore their potential roles in developmental neurobiology and neurodegenerative diseases, respectively, as it has already been shown that the dysfunction of TRP channels localized in the brain contributed to Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), and Amyotrophic lateral sclerosis (LS) (Rather et al., 2023). The gene discussed is TRPV3; the disease is Leigh syndrome.