VIP and dementia: The principal component analysis showed that while most sub-populations were not affected in the demented brain, others were significantly separated, most notably in oligodendrocytes’ precursors as well as in some GABAergic cortical interneurons (Lamp5 and vip), thus highlighting the importance of considering cellular heterogeneity when studying TRP channel involvement in dementia, and suggesting a potential impact on inhibitory neurotransmission in the process (Figure 4B; Supplementary Figures S8B,E).