IL1R1 and major depressive disorder: Our study findings suggest that although IL1R1 exhibits the highest expression level in cardiomyocytes and trigeminal ganglia, our targeted analysis of specific brain regions reveals that localized overexpression of IL1R1 in the olfactory bulb, corpus callosum, and key brain regions (Ashmun et al., 1986) indicates its potential role in regulating neurobiological processes to counteract depression development.