Sang et al. observed the expression of TRPV1 in skin herpes zoster lesions with immunofluorescent staining, which shows that it was increased and mainly present on epidermal keratinocytes compared with control skin, so they conclude that this receptor contributes to acute zoster pain and that there is a combination between nociceptive and neuropathic pain due to peripheral nerve sensitization (Han et al., 2016). The gene discussed is TRPV1; the disease is herpes zoster.