FTR1, CCC2, the essential genes participating in reductive iron acquisition pathway, PGA7, the essential gene involving in the heme iron absorption pathway, SIT1, the critical gene in siderophore iron uptake pathway, and two regulators, SEF1 and HAP43, of iron homeostasis were upregulated when the iron deficiency was encountered (Chen et al., 2011; Ramanan and Wang, 2000; Heymann et al., 2002; Weissman et al., 2002; Kuznets et al., 2014). The gene discussed is SLC12A1; the disease is Iron deficiency anemia.