TP53 and cancer: It is reported that the cause of over 2,400 different genetic diseases in involved in at least one nonsense mutation (Mort et al., 2008; Linde and Kerem, 2008), such as cystic fibrosis (Peltz et al., 2013), Duchenne muscular dystrophy (Nguengang et al., 2020), Spinal muscular atrophy (Li et al., 2019), and tumour suppressor PTEN and p53 mutations caused cancers (Ferguson et al., 2019; Luna et al., 2021).