In addition, Xie et al. demonstrated in vivo and ex vivo that simvastatin could induce pyroptosis through the ROS/caspase-1/GSDMD pathway, inhibit the proliferation of CRC cells, and suppress the growth and weight of tumors, inhibiting the progression of CRC disease (Xie et al., 2023). The gene discussed is CASP1; the disease is colorectal carcinoma.