In vivo experiments showed that 10 mg/kg of EN inhibited autophagy through activation of the mTOR signaling pathway, reduced tumor volume by 58.8%, downregulated the expression of the proliferation marker Ki-67, upregulated the level of the autophagy substrate p62, and inhibited vascular endothelial growth factor (VEGF)-induced angiogenesis, reducing lumen formation and endothelial cell migration (Ye et al., 2022). Here, VEGFA is linked to neoplasm.