GPX4 and colorectal carcinoma: Sui et al. demonstrated through cell experiment that ferroptosis inducers upregulated the expression of ROS in HCT116, LoVo, and HT29 cells, and at the same time, reduced the level of GPX4 in order to inhibit the activity and proliferation of CRC cells, and exerted anti-tumor effect (Sui et al., 2018).