Using MTT, wound healing assay, Transwell and Western blot assays, it was found that FAN (0–9 μM) inhibited cell migration and invasion, suppressed the expression of Caspase-3/9 and Bax, downregulated the level of Bcl-2, and induced apoptosis and G1-phase cell cycle arrest to reverse CRC progression. Here, CASP3 is linked to colorectal carcinoma.