The results showed that Scop (0, 100, 200, and 300 μM) inhibited the activity and proliferation of CRC cells in a dose-dependent manner, and western blot showed that Scop upregulated the expression of LC3-II, ATG5, and Beclin1, and lowered the levels of P62, PAK1, AKT, and mTOR, which was related to the inhibition of AKT/mTOR signaling pathway to promote the cell proliferation. This evidence concerns the gene BECN1 and colorectal carcinoma.