BCL2 and colorectal carcinoma: Zheng et al. reported that UA inhibited the growth of CRC cells through a multi-target regulatory mechanism, significantly induced apoptosis in RKO cells, blocked the cell cycle in G0/G1 phase, and downregulated the expression of Bcl-2, upregulated the expression of Bax, and activated the caspase-3/8/9 cascade response.