Previous studies have demonstrated that CCL2 expression is elevated in infarcted myocardial tissue (Chen and Frangogiannis, 2021), promoting cardiac regeneration through the activation of STAT3 signaling, thereby highlighting its potential therapeutic role in myocardial infarction (MI) and related heart failure (Wang et al., 2024). The gene discussed is STAT3; the disease is myocardial infarction.