The association between SNPs located within the BTBD7 and PLCB1 genes and serological response to bacterial pathogens is not clear; however, the BTBD7 gene has been associated with indicators of heat stress in Holstein cattle and is involved in other biological processes such as development and tumour progression (Luo et al., 2022; Liu et al., 2023). Here, BTBD7 is linked to neoplasm.