Lastly, mice with a loss-of-function variant in Crif1 (CR6-interacting factor-1), encoding a protein that participates in oxidative phosphorylation by regulating the insertion of polypeptides into the inner mitochondrial membrane, developed podocyte injury, glomerular sclerosis and marked albuminuria (Na et al., 2021). Here, GADD45GIP1 is linked to glomerulosclerosis.