Adriamycin injured mice with knockout of synaptopodin (Synpo), which encodes an actin-associated protein, showed worsened podocyte injury and glomerular disease due to loss of actin stress fibers, impaired cell migration, mislocalization and decreased expression of alpha-actinin-4, (ACTN4) and altered activity levels of RHOA and RAC1 (Ning et al., 2020). This evidence concerns the gene ACTN4 and glomerular disorder.