NPHS1 and nephrotic syndrome: Variants in nephrin (NPHS1) and podocin (NPHS2), both encoding slit diaphragm transmembrane proteins, are also causative for Mendelian forms of nephrotic syndrome (Verma et al., 2018; Kestila et al., 1998; Ruotsalainen et al., 2000; Welsh and Saleem, 2010; Boute et al., 2000).