PHGDH and liver cancer: Studies have demonstrated that in liver cancer cells, the aspartate kinase-chorismate mutase-tyrosine aminotransferase (ACT) domain of PHGDH binds to nuclear cMyc, forming a transactivation axis involving PHGDH, p300, cMyc, and AF9, which drives the gene expression of chemokines CXCL1 and IL8.