ANXA2 and non-small cell lung carcinoma: For instance, in human non-small cell lung cancer (NSCLC), Annexin A2 (ANXA2) signals through the TLR2/MYD88 axis in neutrophils, inducing ARG1 mRNA expression through amino acid depletion, which in turn inhibits T-cell viability (Zhang et al., 2022b).