KCNJ15 and Hyperchloremia: In mouse kidneys, Kir4.2 and Kir5.1 are located on the basolateral membrane in the form of heterotetramers (Schlingmann et al., 2021), and hyperchloremia acidosis, reduced threshold for bicarbonate reabsorption, and decreased urinary NH4+ can be observed in KCNJ15−/− mice (Bignon et al., 2020).