For example, the characteristic of ANXA5 inhibits the binding between amyloid β and PS, resulting in the accumulation of neurotoxic amyloid β in the choroid plexus of Alzheimer’s disease patients, ultimately leading to cellular death (Bartolome et al., 2020; Lee et al., 2002) (Figure 1C). The gene discussed is ANXA5; the disease is early-onset autosomal dominant Alzheimer disease.