Through this mechanism, ANXA5 alleviates the immunosuppressive effects induced by chemotherapy and enhances the antitumor efficacy and immunogenicity of tumor antigen-specific immune responses (Bondanza et al., 2004; Chaurio et al., 2009; Frey et al., 2009; Gray et al., 2016). This evidence concerns the gene ANXA5 and neoplasm.