This characteristic is particularly significant, making ANXA5 participate in various biological processes in vivo, including vesicle transport, mineralization in the extracellular matrix, neurotoxicity in Alzheimer’s disease, anticoagulation and antithrombotic, apoptosis regulation and detection, and inhibition of tumor cell growth (Krey et al., 2016). This evidence concerns the gene ANXA5 and early-onset autosomal dominant Alzheimer disease.