To investigate the function of SMURF1 in the proliferation and migration of pancreatic cancer cells, SMURF1 was inhibited using the Smurf1-IN-A01 inhibitor, and the inhibitory effects on pancreatic cancer cells were verified using the in vitro CCK-8 assay, EdU assay, colony formation assay and scratch assay. Here, SMURF1 is linked to pancreatic neoplasm.