Notably, TP53 mutations, classified as either single-hit (n=3) or multi-hit (n=4) according to ICC criteria (1), have shown a longer median latency from primary disease compared to TP53 wild-type [8.2 years (IQR: 4.6–19.3) vs. 6.1 years (IQR: 1.9–17.0), p=0.044] (Figure 2). The gene discussed is TP53; the disease is intrahepatic cholangiocarcinoma.