MDM2 as a p53 ubiquitination complex is one of the ten main targets of curcumin based on a networking analysis and is closely related to the PI3K/Akt signaling pathway, ErbB pathway, hypoxia-inducible factor-1 pathway, and forkhead box O (FOXO) pathway, which are involved in the process of cancer cell proliferation, angiogenesis, invasion, metastasis, and chemotherapy resistance [21]. This evidence concerns the gene TP53 and cancer.