To achieve this, we utilized qPCR to evaluate the mRNA expression levels of stemness-related genes (ALDH1A1, CD44, BMI-1, KLF-4, SOX2, OCT4, and NANOG) in the ovarian cancer cell lines SKOV3, CAOV3, OVCAR4, SK-3rd, and SKDDP treated with cisplatin and Ivosidenib either individually or in combination. This evidence concerns the gene POU5F1 and ovarian carcinoma.