On the other hand, type III interferon, IFN-λ, activates the JAK/STAT pathway through its receptor complex, which includes interferon lambda receptor 1 (IFNLR1) and interleukin-10 receptor 2 (IL-10R2), to regulate immune cells, thereby reducing inflammation and preventing an exaggerated immune response that can cause autoimmunity. Here, IFNLR1 is linked to Autoimmunity.