NPHS1 and focal segmental glomerulosclerosis: Furthermore, patients positive for anti-nephrin antibodies before kidney transplantation showed an increased risk of recurrent disease (hazard ratio 4.9; 95% confidence interval 1.25–18.8; P < .001), raising the question of the need to screen patients with a histological diagnosis of MCD or primary FSGS before transplantation and putative pre-emptive antibody-targeting therapy before kidney transplantation.