The identification of anti-nephrin antibodies as the pathogenic factor in a subset of patients with primary podocytopathies opens a novel, pathomechanisms-based understanding and future classification of antibody-mediated podocytopathies in both adults and children, potentially voiding the current disease description based on histological pattern as in MCD or FSGS in adults or classification as ‘idiopathic’ nephrotic syndrome in children [18]. This evidence concerns the gene NPHS1 and nephrotic syndrome.