The combination of TI/NK cell in primary AML cells increased the expression of pro-apoptotic genes (Bax and Bad) and Bax/Bcl-2 ratio and the percentage of anti-apoptotic genes (Bcl-2 and Bcl-xl) decreased significantly compared to single NK cell treated group (Fig. 7A, B, C, D and E). This evidence concerns the gene BCL2 and acute myeloid leukemia.