The traditional Chinese medicine Aurantii Fructus Immaturus-Carbonisata has demonstrated significant antidepressant effects by upregulating Tph2 expression in the cortex of mice, thereby reducing immobility time in both the CUMS model and the reserpine-induced pain-depression dyad model (Li et al., 2023). The gene discussed is TPH2; the disease is depressive symptom measurement.