NFKB1 and Cowden disease: Upregulation of circ_102685, circ_0062142, circSMAD4, circPRKARIB, and circ103124 in the intestinal mucosa tissues of CD patients and modulates key pathways (p53, TLR/NF-κB, IL-17, and JAK2/STAT3), perpetuating chronic inflammation (29, 31–34).