In line with this study, a combination of radiotherapy, anti-PD-L1 and anti-TIM-3 has been shown to inhibit tumor growth, improve survival, enhance the cytotoxic activity of T cells and decrease infiltration of Tregs in a murine model of head and neck squamous cell carcinoma (HNSCC) (81). The gene discussed is CD274; the disease is head and neck squamous cell carcinoma.