CSF2 and melanoma: The combination of ICIs namely ipilimumab or pembrolizumab and talimogene laherparepvec- a genetically modified oncolytic herpes simplex virus 1 that express granulocyte-macrophage colony-stimulating factor (GM-CSF)-demonstrated improved therapeutic potential in treating unresectable melanoma patients in comparison to monotherapy without any additional safety concerns (131–135).