The levels of E-Selectin, ICAM, and VCAM remained unaffected with cholecalciferol supplementation, supporting the findings of a recent systematic review and meta-analysis of RCTs on metabolic syndrome and related disorders that reported no effect of vitamin D supplementation on E-Selectin, ICAM-1, VCAM-1, and endothelin levels (35). The gene discussed is VCAM1; the disease is metabolic syndrome.