Beyond MMP regulation, in the context of cancer, TIMP‐4 can influence various signalling pathways, including Notch, Hedgehog, TGF‐β, phosphatidylinositol 3‐kinase (PI‐3K), nuclear factor kappa B (NFκB), and Janus kinase (JAK) signal transducer and activator of transcription (JAK/STAT), which are essential for tumour progression and maintenance [66]. This evidence concerns the gene NFKB1 and cancer.