An intriguing hypothesis is that hormones regulating skeletal turnover (i.e., 25OH vitamin D [25OHD] and parathyroid hormone) and/or those secreted by bone cells under physiological and pathological conditions (i.e., fibroblast growth factor 23) could play a significant role in the pathogenesis of cardiovascular disorders [16, 62, 63]. The gene discussed is PTH; the disease is cardiovascular disorder.